CAS.checksum            Test the check digit of a CAS number to confirm
                        validity
EPA.ref                 Reference for EPA Physico-Chemical Data
Frank2018invivo         Literature In Vivo Data on Doses Causing
                        Neurological Effects
Obach2008               Published Pharmacokinetic Parameters from Obach
                        et al. 2008
Tables.Rdata.stamp      A timestamp of table creation
Wetmore2012             Published toxicokinetic predictions based on in
                        vitro data from Wetmore et al. 2012.
add_chemtable           Add a table of chemical information for use in
                        making httk predictions.
age_draw_smooth         Draws ages from a smoothed distribution for a
                        given gender/race combination
apply_clint_adjustment
                        Correct the measured intrinsive hepatic
                        clearance for fraction free
apply_fup_adjustment    Correct the measured fraction unbound in plasma
                        for lipid binding
armitage_estimate_sarea
                        Estimate well surface area
armitage_eval           Evaluate the updated Armitage model
armitage_input          Armitage et al. (2014) Model Inputs from Honda
                        et al. (2019)
augment.table           Add a parameter value to the
                        chem.physical_and_invitro.data table
available_rblood2plasma
                        Find the best available ratio of the blood to
                        plasma concentration constant.
aylward2014             Aylward et al. 2014
benchmark_httk          Assess the current performance of httk relative
                        to historical benchmarks
blood_mass_correct      Find average blood masses by age.
blood_weight            Predict blood mass.
bmiage                  CDC BMI-for-age charts
body_surface_area       Predict body surface area.
bone_mass_age           Predict bone mass
brain_mass              Predict brain mass.
calc_analytic_css       Calculate the analytic steady state plasma
                        concentration.
calc_analytic_css_1comp
                        Calculate the analytic steady state
                        concentration for the one compartment model.
calc_analytic_css_3comp
                        Calculate the analytic steady state
                        concentration for model 3comp
calc_analytic_css_3compss
                        Calculate the analytic steady state
                        concentration for the three compartment
                        steady-state model
calc_analytic_css_pbtk
                        Calculate the analytic steady state plasma
                        concentration for model pbtk.
calc_css                Find the steady state concentration and the day
                        it is reached.
calc_dow                Calculate the distribution coefficient
calc_elimination_rate   Calculate the elimination rate for a one
                        compartment model
calc_fbio.oral          Functions for calculating the bioavaialble
                        fractions from oral doses
calc_fetal_phys         Calculate maternal-fetal physiological
                        parameters
calc_fup_correction     Calculate the correction for lipid binding in
                        plasma binding assay
calc_half_life          Calculates the half-life for a one compartment
                        model.
calc_hep_bioavailability
                        Calculate first pass heaptic metabolism
calc_hep_clearance      Calculate the hepatic clearance.
calc_hep_fu             Calculate the free chemical in the hepaitic
                        clearance assay
calc_hepatic_clearance
                        Calculate the hepatic clearance (deprecated).
calc_ionization         Calculate the ionization.
calc_kair               Calculate air:matrix partition coefficients
calc_krbc2pu            Back-calculates the Red Blood Cell to Unbound
                        Plasma Partition Coefficient
calc_ma                 Calculate the membrane affinity
calc_maternal_bw        Calculate maternal body weight
calc_mc_css             Distribution of chemical steady state
                        concentration with uncertainty and variability
calc_mc_oral_equiv      Calculate Monte Carlo Oral Equivalent Dose
calc_mc_tk              Conduct multiple TK simulations using Monte
                        Carlo
calc_rblood2plasma      Calculate the constant ratio of the blood
                        concentration to the plasma concentration.
calc_stats              Calculate toxicokinetic summary statistics
                        (deprecated).
calc_tkstats            Calculate toxicokinetic summary statistics.
calc_total_clearance    Calculate the total plasma clearance.
calc_vdist              Calculate the volume of distribution for a one
                        compartment model.
chem.invivo.PK.aggregate.data
                        Parameter Estimates from Wambaugh et al. (2018)
chem.invivo.PK.data     Published toxicokinetic time course
                        measurements
chem.invivo.PK.summary.data
                        Summary of published toxicokinetic time course
                        experiments
chem.physical_and_invitro.data
                        Physico-chemical properties and in vitro
                        measurements for toxicokinetics
ckd_epi_eq              CKD-EPI equation for GFR.
concentration_data_Linakis2020
                        Concentration data involved in Linakis 2020
                        vignette analysis.
convert_httkpop_1comp   Converts HTTK-Pop physiology into parameters
                        relevant to the one compartment model
convert_solve_x         convert_solve_x
convert_units           convert_units
create_mc_samples       Create a table of parameter values for Monte
                        Carlo
dawson2021              Dawson et al. 2021 data
estimate_gfr            Predict GFR.
estimate_gfr_ped        Predict GFR in children.
estimate_hematocrit     Generate hematocrit values for a virtual
                        population
example.seem            SEEM Example Data We can grab SEEM daily intake
                        rate predictions already in RData format from
                        https://github.com/HumanExposure/SEEM3RPackage/tree/main/SEEM3/data
                        Download the file Ring2018Preds.RData
example.toxcast         ToxCast Example Data The main page for the
                        ToxCast data is here:
                        https://www.epa.gov/comptox-tools/exploring-toxcast-data
                        Most useful to us is a single file containing
                        all the hits across all chemcials and assays:
                        https://clowder.edap-cluster.com/datasets/6364026ee4b04f6bb1409eda?space=62bb560ee4b07abf29f88fef
export_pbtk_jarnac      Export model to jarnac.
export_pbtk_sbml        Export model to sbml.
fetalpcs                Fetal Partition Coefficients
gen_age_height_weight   Generate demographic parameters for a virtual
                        population
gen_height_weight       Generate heights and weights for a virtual
                        population.
gen_serum_creatinine    Generate serum creatinine values for a virtual
                        population.
get_caco2               Retrieve in vitro measured Caco-2 membrane
                        permeabilit
get_chem_id             Retrieve chemical identity from HTTK package
get_cheminfo            Retrieve chemical information available from
                        HTTK package
get_clint               Retrieve and parse intrinsic hepatic clearance
get_fabsgut             Retrieve or calculate fraction of chemical
                        absorbed from the gut
get_fup                 Retrieve and parse fraction unbound in plasma
get_gfr_category        Categorize kidney function by GFR.
get_invitroPK_param     Retrieve species-specific in vitro data from
                        chem.physical_and_invitro.data table
get_lit_cheminfo        Get literature Chemical Information.
get_lit_css             Get literature Css
get_lit_oral_equiv      Get Literature Oral Equivalent Dose
get_physchem_param      Get physico-chemical parameters from
                        chem.physical_and_invitro.data table
get_rblood2plasma       Get ratio of the blood concentration to the
                        plasma concentration.
get_weight_class        Assign weight class (underweight, normal,
                        overweight, obese)
get_wetmore_cheminfo    Get literature Chemical Information.
                        (deprecated).
get_wetmore_css         Get literature Css (deprecated).
get_wetmore_oral_equiv
                        Get Literature Oral Equivalent Dose
                        (deprecated).
hct_h                   KDE bandwidths for residual variability in
                        hematocrit
hematocrit_infants      Predict hematocrit in infants under 1 year old.
honda.ivive             Return the assumptions used in Honda et al.
                        2019
honda2023.data          Measured Caco-2 Apical-Basal Permeability Data
honda2023.qspr          Predicted Caco-2 Apical-Basal Permeabilities
howgate                 Howgate 2006
httk.performance        Historical Performance of R Package httk
httkpop                 httkpop: Virtual population generator for HTTK.
httkpop_biotophys_default
                        Convert HTTK-Pop-generated parameters to HTTK
                        physiological parameters
httkpop_direct_resample
                        Generate a virtual population by directly
                        resampling the NHANES data.
httkpop_direct_resample_inner
                        Inner loop function called by
                        'httkpop_direct_resample'.
httkpop_generate        Generate a virtual population for PBTK
httkpop_mc              httk-pop: Correlated human physiological
                        parameter Monte Carlo
httkpop_virtual_indiv   Generate a virtual population by the virtual
                        individuals method.
hw_H                    KDE bandwidth for residual variability in
                        height/weight
in.list                 Convenience Boolean (yes/no) functions to
                        identify chemical membership in several key
                        lists.
invitro_mc              Monte Carlo for in vitro toxicokinetic
                        parameters including uncertainty and
                        variability.
is.httk                 Convenience Boolean (yes/no) function to
                        identify chemical membership and treatment
                        within the httk project.
is_in_inclusive         Checks whether a value, or all values in a
                        vector, is within inclusive limits
johnson                 Johnson 2006
kapraun2019             Kapraun et al. 2019 data
kidney_mass_children    Predict kidney mass for children
liver_mass_children     Predict liver mass for children
load_dawson2021         Load CLint and Fup QSPR predictions from Dawson
                        et al. 2021.
load_honda2023          Load Caco2 QSPR predictions from Honda et al.
                        2023
load_pradeep2020        Load CLint and Fup QSPR predictions predictions
                        from Pradeep et al. 2020.
load_sipes2017          Load CLint and Fup QSPR predictions from Sipes
                        et al 2017.
lump_tissues            Lump tissue parameters into model compartments
lung_mass_children      Predict lung mass for children
mcnally_dt              Reference tissue masses and flows from tables
                        in McNally et al. 2014.
mecdt                   Pre-processed NHANES data.
metabolism_data_Linakis2020
                        Metabolism data involved in Linakis 2020
                        vignette analysis.
monte_carlo             Monte Carlo for toxicokinetic model parameters
onlyp                   NHANES Exposure Data
pancreas_mass_children
                        Predict pancreas mass for children
parameterize_1comp      Parameters for a one compartment (empirical)
                        toxicokinetic model
parameterize_3comp      Parameters for a three-compartment
                        toxicokinetic model (dynamic)
parameterize_fetal_pbtk
                        Parameterize_fetal_PBTK
parameterize_gas_pbtk   Parameters for a generic gas inhalation
                        physiologically-based toxicokinetic model
parameterize_pbtk       Parameters for a generic physiologically-based
                        toxicokinetic model
parameterize_schmitt    Parameters for Schmitt's (2008) Tissue
                        Partition Coefficient Method
parameterize_steadystate
                        Parameters for a three-compartment
                        toxicokinetic model at steady-state
pc.data                 Partition Coefficient Data
pearce2017regression    Pearce et al. 2017 data
pharma                  DRUGS|NORMAN: Pharmaceutical List with EU,
                        Swiss, US Consumption Data
physiology.data         Species-specific physiology parameters
pksim.pcs               Partition Coefficients from PK-Sim
pradeep2020             Pradeep et al. 2020
predict_partitioning_schmitt
                        Predict partition coefficients using the method
                        from Schmitt (2008).
pregnonpregaucs         AUCs for Pregnant and Non-Pregnant Women
propagate_invitrouv_1comp
                        Propagates uncertainty and variability in in
                        vitro HTTK data into one compartment model
                        parameters
propagate_invitrouv_3comp
                        Propagates uncertainty and variability in in
                        vitro HTTK data into three compartment model
                        parameters
propagate_invitrouv_pbtk
                        Propagates uncertainty and variability in in
                        vitro HTTK data into PBPK model parameters
r_left_censored_norm    Returns draws from a normal distribution with a
                        lower censoring limit of lod (limit of
                        detection)
reset_httk              Reset HTTK to Default Data Tables
rfun                    Randomly draws from a one-dimensional KDE
rmed0non0u95            Draw random numbers with LOD median but
                        non-zero upper 95th percentile
scale_dosing            Scale mg/kg body weight doses according to body
                        weight and units
scr_h                   KDE bandwidths for residual variability in
                        serum creatinine
set_httk_precision      set_httk_precision
sipes2017               Sipes et al. 2017 data
skeletal_muscle_mass    Predict skeletal muscle mass
skeletal_muscle_mass_children
                        Predict skeletal muscle mass for children
skin_mass_bosgra        Predict skin mass
solve_1comp             Solve one compartment TK model
solve_3comp             Solve_3comp
solve_fetal_pbtk        Solve_fetal_PBTK
solve_gas_pbtk          solve_gas_pbtk
solve_model             Solve_model
solve_pbtk              Solve_PBTK
spleen_mass_children    Predict spleen mass for children
supptab1_Linakis2020    Supplementary output from Linakis 2020 vignette
                        analysis.
supptab2_Linakis2020    More supplementary output from Linakis 2020
                        vignette analysis.
tissue.data             Tissue composition and species-specific
                        physiology parameters
tissue_masses_flows     Given a data.table describing a virtual
                        population by the NHANES quantities, generates
                        HTTK physiological parameters for each
                        individual.
tissue_scale            Allometric scaling.
wambaugh2019            in vitro Toxicokinetic Data from Wambaugh et
                        al. (2019)
wambaugh2019.nhanes     NHANES Chemical Intake Rates for chemicals in
                        Wambaugh et al. (2019)
wambaugh2019.raw        Raw Bayesian in vitro Toxicokinetic Data
                        Analysis from Wambaugh et al. (2019)
wambaugh2019.seem3      ExpoCast SEEM3 Consensus Exposure Model
                        Predictions for Chemical Intake Rates
wambaugh2019.tox21      Tox21 2015 Active Hit Calls (EPA)
wang2018                Wang et al. 2018 Wang et al. (2018) screened
                        the blood of 75 pregnant women for the presence
                        of environmental organic acids (EOAs) and
                        identified mass spectral features corresponding
                        to 453 chemical formulae of which 48 could be
                        mapped to likely structures. Of the 48 with
                        tentative structures the identity of six were
                        confirmed with available chemical standards.
well_param              Microtiter Plate Well Descriptions for Armitage
                        et al. (2014) Model
wfl                     WHO weight-for-length charts
